I've compiled ffmpeg with emscripten and used it successfully, after compiling just with -msimd128 I get this error in chrome:
Compiling function #59 failed: f32x4.splat[0] expected type f32, found i64.const of type i64 @+26296)
I'm not an expert about SIMD and as the code compiles succusfully, don't know if this feature is not implemented in Chrome or it's a bug with emscripten.
I'm using emcc 1.39.18 and chrome 83 with "WebAssembly SIMD support" flag on.